Although it tends to underperform defensively due to the presence of dangerous threats such as Aegislash as well as competition with other Spikers like Skarmory, Mew still has great bulk for the tier and can sport a good amount of utility for teams with entry hazard setting or removal. Mew can easily set Spikes against foes such as Buzzwole and Skarmory, and it can even set the hazard against offensive threats such as Mega Latias and Rotom-Wash. Mew can also switch into and remove entry hazards against Skarmory and Clefable with Defog. Will-O-Wisp allows Mew to cripple wallbreakers such as Bisharp and Scizor. In a pinch, Will-O-Wisp can also be used to prevent faster threats like Zeraora and Iron Boulder from causing havoc. Knock Off has good synergy with Spikes to remove Heavy-Duty Boots from threats like Slowbro, Iron Moth, and Zeraora while still being able to punish Choice-locked wallbreakers such as Keldeo and Hydreigon. Psychic allows Mew to immediately pressure threats like Iron Moth, Amoonguss, and Mega Venusaur, while Night Shade can provide consistent damage into threats such as Celesteela. Mew's EV spread is invested to outrun Adamant Choice Band Buzzwole, but it is flexible enough to run slower spreads like 16 Speed EVs to just outrun Bisharp. Mew best fits on balance teams looking to find a valuable role compression option that can set or control entry hazards while still blanket checking a ton of threats, such as Buzzwole and Iron Boulder, which helps to enable teammates such as Mienshao, Scizor, and Iron Moth. Common pivots such as Rotom-Wash and Victini can easily force Mew in and pivot out to checks such as Aegislash, so partners that can block or punish their pivoting such as Swampert and Zeraora as well as Rocky Helmet users like Clefable and Rotom-Wash are appreciated. Mew hates offensive Dark-types like Lokix, Hydreigon, and Tyranitar even if it can punish them, so it enjoys additional partners like Mienshao and Keldeo to force them out. Aegislash is a big roadblock for Mew, so pairing it up with Iron Moth and Bisharp is great for it; in return, Mew can harass their common checks such as Swampert and Mega Venusaur. Spikes Mew can also pair nicely with Stealth Rock users like Clefable, and Hippowdon to overwhelm entry hazard removers such as Excadrill and Rotom-Wash. Partners that can take advantage of Rotom-Wash's attempts to use Defog, such as Bisharp, also are valuable to Mew in order to let it set Spikes freely.

Mew is a good lead option for hyper offense teams as its better bulk compared to other leads allows it to set both Stealth Rock and Spikes and prevent opposing entry hazards and Defog attempts with Taunt. However, Mew suffers competition from lead Excadrill, which is capable of setting up Stealth Rock against Mega Sableye and remove entry hazards with Rapid Spin, something heavily appreciated by Stealth Rock weak Pokemon like Iron Moth. Taunt prevents Defog from slower targets like Rotom-Wash, setup attempts from Pokemon like Nasty Plot Hydreigon, and Stealth Rock and Spikes from setters like Excadrill and Skarmory, respectively . Explosion allows Mew to generate momentum and hinder entry hazard removers like Hydreigon and Excadrill from removing entry hazards with Defog or Rapid Spin, respectively. Flare Blitz can be used to heavily dent Steel-types like Excadrill and Scizor, but it's a worse option overall, as it lacks consistency to KO itself with the recoil, unlike Explosion. Red Card works well to force out opposing lead Excadrill and setup sweepers like Nasty Plot Thundurus if Mew survives a hit. Lead Mew fits best on hyper offense teams where it can support its teammates by setting up entry hazards. Air Balloon Aegislash and Sinistcha are great partners capable of spinblocking Excadrill; they appreciate Mew's entry hazards weakening walls such as Celesteela or in Aegislash's case weakening fast revenge killers like Iron Moth and Mega Aerodactyl into Shadow Sneak KO range. Wallbreakers like Swords Dane Mega Gallade and Calm Mind Keldeo can easily set up against Dark-types that Mew lures in like Tyranitar and Hydreigon. Nasty Plot Thundurus is another great partner that can pressure Defoggers like Serperior and Rotom-Wash to keep entry hazards up for the rest of team. Late-game cleaners like Autotomize Celesteela, Booster Energy Iron Moth, and Double Dance Galarian Moltres enjoy Mew preventing Steath Rock with Taunt and its Spikes potentially putting Tyranitar in Energy Ball and Supersonic Skystrike KO range, respectively. Finally, since Mew lacks the ability to get entry hazards up against Mega Sableye, good partners that can pressure it like Nasty Plot Thundurus and Galarian Moltres make for great options.