With solid physical bulk, a good defensive typing, and Regenerator, Amoonguss gives stall teams a reliable answer to specific physical wallbreakers such as Ogerpon-W, Zamazenta, and Urshifu-R. Giga Drain lets Amoonguss threaten Great Tusk and Mega Tyranitar, preventing them from taking advantage of it too easily. Synthesis further improves Amoonguss's longevity, letting it stay healthy when it needs to remain in front of these threats or when switching out to take advantage of Regenerator is not ideal. Spore lets Amoonguss put one foe to sleep, giving its teammates more room to make progress even in matchups where Amoonguss is otherwise passive. Sludge Bomb hits Fairy- and Grass-types such as Iron Valiant, Tapu Koko, and Rillaboom and can punish switch-ins like Garchomp, Cinderace, and Mega Medicham with poison. Clear Smog is an alternative to prevent setup sweepers that don't immediately threaten Amoonguss, such as Calm Mind Raging Bolt and non-Z move Dragon Dance Dragonite, from snowballing out of control. Heavy-Duty Boots helps Amoonguss avoid being worn down by entry hazards, which is especially important because it is expected to switch in repeatedly.

Amoonguss fits exclusively on stall teams that need a sturdy answer to wallbreakers like Ogerpon-W and Urshifu-R. Due to its passivity, it needs teammates that can punish the Steel- and Poison-types that use it as an entry point, such as Gholdengo, Heatran, Mega Scizor, Kingambit, and Pecharunt. Clodsire is especially valuable for handling Gholdengo, Pecharunt, Heatran, and Volcarona, while Gliscor can absorb Knock Off, pressure Gholdengo, and make progress with Spikes. Corviknight and Skarmory further support Amoonguss by switching into opposing Corviknight, which walls Amoonguss and can freely use it as an entry point once a different foe has been put to sleep. Corviknight also checks Kyurem, Tapu Lele, and Hatterene, while Skarmory provides a sturdier answer to Weavile with Body Press. Magic Guard Clefable absorbs Knock Off and eases pressure from physical wallbreakers such as Mega Lopunny, Mega Tyranitar, and Hisuian Samurott without being worn down by entry hazards or status. Dondozo handles physical setup sweepers such as Dragonite, Mega Charizard X, Ceruledge, and Blaziken. Blissey covers special attackers such as Kyurem, Terapagos, Mega Latios, Raging Bolt, and Mega Charizard Y, whereas Mega Sableye helps against Psychic-types like Mega Medicham, whose STAB moves can overwhelm Amoonguss.

Specially defensive Amoonguss uses its great typing and servicable bulk alongside Regenerator to bolster its team against threats like Zeraora, Enamorus, mixed Aegislash, Clefable, and Rotom-Wash. Despite investing mainly in Special Defense, Amoonguss can still help teams play around certain physical attackers like Buzzwole, Mienshao, Choice Band Iron Boulder, Zeraora, and Scizor. Sludge Bomb hits targets like Enamorus and Clefable harder with the ability to cripple Mega Latias and Mega Gallade as they switch in, but Clear Smog can be used to ease matchups against Calm Mind sweepers like Clefable, Keldeo, and Tapu Fini. Foul Play hits Scizor and Aegislash hard, OHKOing the former at +2 after slight chip damage and the latter at +4 when in Shield Forme or at +2 when in Sword Forme. Spore allows Amoonguss to threaten Celesteela and Skarmory, which would otherwise completely wall it, and significantly improves Amoonguss's threat level if they need to be preserved in a matchup. Stomping Tantrum is only run alongside both Assault Vest and 56 Attack EVs with a Sassy Nature, which allows Amoonguss to OHKO Iron Moth, complemented by the fact that Assault Vest allows Amoonguss to better take attacks like Iron Moth's Fiery Dance, Keldeo's Supersonic Skystrike, and Hydrapple's Devastating Drake. However, Heavy-Duty Boots are preferred to allow Amoonguss to repeatedly switch into threats like Enamorus, Aegislash, and Rotom-Wash without being worn down by entry hazards. The given EV spread allows Amoonguss to survive +2 Shadow Claw from Aegislash and Triple Axel from Choice Scarf Mienshao after Stealth Rock, as Amoonguss is liable to having its Heavy-Duty Boots removed by Knock Off. Specially defensive Amoonguss is typically seen on balance and bulky teams looking for a reliable option to help deal with special attackers that can also reliably absorb status or Knock Off for teammates like Celesteela, Hippowdon, and Gastrodon. While Amoonguss can deal with many special threats, its reliance on Regenerator for healing leaves it liable to being overwhelmed by strong special attackers like Hydrapple and repeated hits from Hydreigon and Aegislash. Teammates such as Celesteela, Blissey, and Scizor can pair together with Amoonguss to handle these attackers more reliably in shorter games while also handling threats like Alakazam and Mega Latias that Amoonguss cannot. In return, Amoonguss can scout the movesets of these options and soak up residual damage long-term, allowing these partners to stay healthy and exert pressure on the opposing team more reliably. While Amoonguss can often scout the movesets of physical threats like Mienshao and Swords Dance Aegislash, reliable counters to these Pokemon such as Buzzwole are recommended to ensure that a team can deal with these Pokemon long-term. Amoonguss also appreciates partners that can set hazards, such as Hippowdon, Clefable, Skarmory, and Blissey, as they ensure that it can wear down the attackers it's tasked with handling while it remains healthy itself.