Specially defensive Amoonguss uses its great typing and servicable bulk alongside Regenerator to bolster its team against threats like Zeraora, Enamorus, mixed Aegislash, Clefable, and Rotom-Wash. Despite investing mainly in Special Defense, Amoonguss can still help teams play around certain physical attackers like Buzzwole, Mienshao, Choice Band Iron Boulder, Zeraora, and Scizor. Sludge Bomb hits targets like Enamorus and Clefable harder with the ability to cripple Mega Latias and Mega Gallade as they switch in, but Clear Smog can be used to ease matchups against Calm Mind sweepers like Clefable, Keldeo, and Tapu Fini. Foul Play hits Scizor and Aegislash hard, OHKOing the former at +2 after slight chip damage and the latter at +4 when in Shield Forme or at +2 when in Sword Forme. Spore allows Amoonguss to threaten Celesteela and Skarmory, which would otherwise completely wall it, and significantly improves Amoonguss's threat level if they need to be preserved in a matchup. Stomping Tantrum is only run alongside both Assault Vest and 56 Attack EVs with a Sassy Nature, which allows Amoonguss to OHKO Iron Moth, complemented by the fact that Assault Vest allows Amoonguss to better take attacks like Iron Moth's Fiery Dance, Keldeo's Supersonic Skystrike, and Hydrapple's Devastating Drake. However, Heavy-Duty Boots are preferred to allow Amoonguss to repeatedly switch into threats like Enamorus, Aegislash, and Rotom-Wash without being worn down by entry hazards. The given EV spread allows Amoonguss to survive +2 Shadow Claw from Aegislash and Triple Axel from Choice Scarf Mienshao after Stealth Rock, as Amoonguss is liable to having its Heavy-Duty Boots removed by Knock Off. Specially defensive Amoonguss is typically seen on balance and bulky teams looking for a reliable option to help deal with special attackers that can also reliably absorb status or Knock Off for teammates like Celesteela, Hippowdon, and Gastrodon. While Amoonguss can deal with many special threats, its reliance on Regenerator for healing leaves it liable to being overwhelmed by strong special attackers like Hydrapple and repeated hits from Hydreigon and Aegislash. Teammates such as Celesteela, Blissey, and Scizor can pair together with Amoonguss to handle these attackers more reliably in shorter games while also handling threats like Alakazam and Mega Latias that Amoonguss cannot. In return, Amoonguss can scout the movesets of these options and soak up residual damage long-term, allowing these partners to stay healthy and exert pressure on the opposing team more reliably. While Amoonguss can often scout the movesets of physical threats like Mienshao and Swords Dance Aegislash, reliable counters to these Pokemon such as Buzzwole are recommended to ensure that a team can deal with these Pokemon long-term. Amoonguss also appreciates partners that can set hazards, such as Hippowdon, Clefable, Skarmory, and Blissey, as they ensure that it can wear down the attackers it's tasked with handling while it remains healthy itself.